Eric Fischer’s lab focuses on the role of ubiquitination in development and cancer, with special focus on developing novel pharmacologic strategies to target the ubiquitin machinery. The lab combines structural biology, cell biology, proteomics and chemical biology to address the molecular workings of ubiquitin E3 ligase complexes such as CRL4CRBN, and has developed novel mass spectrometry approaches for proteome-wide E3 ligase screens to enable rapid development of degrader molecules (PROTACs). Dr. Fischer collaborates closely with Drs. Gray, Buhrlage, Ebert, Jänne, Kaelin, Livingston, Stegmaier, Qi, Chouchani and Kim. Drs. Chouchani is a co-mentor on this training grant application.