Jon earned his PhD from the University of Berkeley in 2015. He joined the lab of Dr. Hari Arthanari where he studies the structural basis of transcription factor sequence specificity and function. Many transcription factors contain intrinsically disordered regions (IDRs), which are not amenable to structural analyses via X-ray crystallography or cryo EM. These IDR regions also harbor mutations found in cancer, but the roles these regions play in normal cellular function and the roles cancer associated mutations play in disease are not understood. The Arthanari lab is a pioneer in the use of nuclear magnetic microscopy (NMR) for structural studies of IDRs, and Jon will be using the structural clues identified by NMR in a host of transcription factor IDRs to interrogate the roles of these regions. In addition he will be investigating the interaction of transcriptional activation domains (TADs) with the KIX domains of transcriptional mediators such as MED15. These studies will inform small molecule drug design to address aberrant transcription factor activity in cancer cells. Jon joined the CCBM T32 training program to prepare for a career as an independent investigator. The program will provide support, mentoring and exposure to state-of-the-art technologies and set him on a path toward developing a platform to interrogate transcription factors that he will use as the basis for the work of his own lab.